Formulate and adopt a comprehensive National Science and Technology Plan, and monitor and coordinate its funding and implementation;
Promote, assist and, where appropriate, undertake scientific and technological research and development in areas identified as vital to the country's development;
Promote the development of indigenous technology and the adaptation and innovation of suitable imported technology, and in this regard, undertake technology development up to commercial stage;
Undertake design and engineering works to complement research and development functions;
Promote, assist and, where appropriate, undertake the transfer of the results of scientific and technological research and development to their end-users;
Promote, assist and, where appropriate, undertake the technological services needed by agriculture, industry, transport, and the general public;
Develop and maintain an information system and databank on science and technology;
Develop and implement programs for strengthening scientific and technological capabilities through manpower training, infrastructure and institution-building;
Promote public consciousness in science and technology; and,
Undertake policy research, technology assessment, feasibility and technical studies.
In the 90's, DOST's overall mission is embodied in the 1990-2000 Science and Technology Master Plan (STMP) that shows the direction and desired goals of Philippine S&T for both the public and private sectors.